Spero® Chemical Imaging Microscope

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Spero® Chemical Imaging Microscope:
Unrivaled Mid-IR Spectroscopy

In a class of their own, the Spero® and the Spero-QT microscopes are the world’s first and only fully integrated, wide-field spectroscopic microscopy and imaging platforms based on our broadly tunable mid-infrared quantum cascade laser technology.


The Spero system offers unrivaled mid-IR spectroscopy, substantially outperforming FTIR microscopes in spatial resolution, speed, and field-of-view capabilities while eliminating the need for cryogenic cooling. This system is faster than Raman microscopes, by orders of magnitude, and avoids the detrimental effects of auto-fluorescence. Spero microscopes enable new data collection modalities such as real-time chemical imaging and user-defined sparse data collection. Their small desktop footprints makes them suitable for labs with space constraints.


The all-new Spero-QT microscope is the second-generation platform in this new class of instruments and represents yet another breakthrough in IR spectroscopy, with high-performance, label-free chemical imaging. The Spero-QT system has the wide-field, high-resolution attributes of its predecessor but with the capability to produce twice the data in one-tenth of the time, while achieving unprecedented signal-to-noise ratios. The Spero-QT stage can image up to 3 microscope slides, and its larger sample compartment makes the Spero-QT more compatible with microfluidic devices and accessories.

Features & Benefits

  • Real-time, high-throughput spectral imaging enabled by ultra-high
  • Brightness QCL technology
  • No stains or molecular tags required
  • Label-free IR spectroscopy displays pure chemistry of sample
  • No cryogenic cooling needed
  • Quick setup means more time for analysis


  • Biomedical imaging of tissues, cells, and fluids
  • Cancer research
  • Pharmaceutical testing of tablets, powders, and liquids
  • Drug discovery: API and excipient optimization and down-selection
  • Protein secondary structure and aggregation testing
  • Real-time reaction monitoring
  • Materials testing and analysis
  • Forensics
  • Chemical detection and identification

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Spero® Research Papers

We invented it, and then we made it better.

Our Spero microscopes are faster than FTIR and Raman scopes, plus they avoid the need for cryogenic cooling and the complications of autoflorescence. Take a closer look.

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