Featured Publications

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Featured Publications


Label-free, automated classification of microsatellite status in colorectal cancer by infrared imaging

Scientific Reports | June 23, 2020 | DOI: 10.1038/s41598-020-67052-z | A. Kallenbach-Thieltges, et al

Researchers at the Ruhr University Bochum (Bochum, Germany) leveraged label-free QCL-IR imaging to classify for the first time between two sub-types of colorectal cancer referred to as microsatellite instable (MSI) and microsatellite stable (MSS). In a 100 patient study, which did not rely on the use of tissue micro arrays, the researchers were able to achieve 100% sensitivity and 93% specificity. This work paves the way for rapid and cost-effective candidate screening for immunotherapy treatments.

Mid-infrared metabolic imaging with vibrational probes

Nature Methods | June 29, 2020 | DOI: 10.1038/s41592-020-0883-z | L. Shi, et al

Researchers at Columbia University (New York, USA) have developed a series of novel engineered small molecule IR-active probes for highly-specific metabolic imaging. This technique is providing new insights into drug metabolic activity and disease progression in cells and tissues.